Small Molecule Receptor Binding Inhibitors with In Vivo Efficacy against Botulinum Neurotoxin Serotypes A and E

Small Molecule Receptor Binding Inhibitors with In Vivo Efficacy against Botulinum Neurotoxin Serotypes A and E

Botulinum neurotoxins (BoNTs) are the most poisonous substances in nature. Currently, the only therapy for botulism is antitoxin. This therapy suffers from several limitations and hence new therapeutic strategies are desired. One of the limitations in discovering BoNT inhibitors is the absence of an...

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Bibliographic Details
Main Authors: Alon Ben David, Ada Barnea, Eran Diamant, Eyal Dor, Arieh Schwartz, Amram Torgeman, Ran Zichel
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:International Journal of Molecular Sciences
Subjects:
Botulinum neurotoxin
small molecule inhibitors
high throughput screening
antitoxin
Online Access:https://www.mdpi.com/1422-0067/22/16/8577

Internet

https://www.mdpi.com/1422-0067/22/16/8577

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