AIM2 fosters lung adenocarcinoma immune escape by modulating PD-L1 expression in tumor-associated macrophages via JAK/STAT3

AIM2 fosters lung adenocarcinoma immune escape by modulating PD-L1 expression in tumor-associated macrophages via JAK/STAT3

This work was devised to discuss the effect of AIM2 on the immunosuppression of LUAD tumors, as well as its molecular mechanism. An allograft mouse model was built. Mouse macrophages were isolated and collected. The infiltration level of Mø and expression of M1 Mø, M2 Mø markers, and PD-L1 were assa...

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Bibliographic Details
Main Authors: Hua Ye, Wenwen Yu, Yunlei Li, Xiaoqiong Bao, Yangyang Ni, Xiangxiang Chen, Yangjie Sun, Ali Chen, Weilong Zhou, Jifa Li
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:Human Vaccines & Immunotherapeutics
Subjects:
aim2
jak/stat3
tumor-associated macrophage
pd-l1
lung adenocarcinoma
immune escape
Online Access:http://dx.doi.org/10.1080/21645515.2023.2269790

Internet

http://dx.doi.org/10.1080/21645515.2023.2269790

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