Oncolytic vaccinia virus injected intravenously sensitizes pancreatic neuroendocrine tumors and metastases to immune checkpoint blockade

Oncolytic vaccinia virus injected intravenously sensitizes pancreatic neuroendocrine tumors and metastases to immune checkpoint blockade

This study determined the influence of intravenous (i.v.) oncolytic vaccinia virus mpJX-594 (mpJX) on antitumor activity of anti-programmed death receptor-1 antibody (aPD1) in functional and metastatic pancreatic neuroendocrine tumors (PanNETs). One i.v. dose of mpJX, engineered for mice with the sa...

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Bibliographic Details
Main Authors: Mitsuko Inoue, Minah Kim, Tomoyoshi Inoue, Madeline Tait, Thomas Byrne, Maximilian Nitschké, Patrizia Murer, Howard Cha, Aishwarya Subramanian, Naomi De Silva, Teresa Chiaverotti, Donald M. McDonald
Format: Article
Language:English
Published: Elsevier 2022-03-01
Series:Molecular Therapy: Oncolytics
Subjects:
apoptosis
cytotoxic T cells
NK cells
insulin
hypoglycemia
liver metastasis
Online Access:http://www.sciencedirect.com/science/article/pii/S2372770521001881

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http://www.sciencedirect.com/science/article/pii/S2372770521001881

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