Genomic characterization and immunotherapy for microsatellite instability-high in cholangiocarcinoma

Genomic characterization and immunotherapy for microsatellite instability-high in cholangiocarcinoma

Abstract Background Microsatellite instability-high (MSI-H) is a unique genomic status in many cancers. However, its role in the genomic features and immunotherapy in cholangiocarcinoma (CCA) is unclear. This study aimed to systematically investigate the genomic characterization and immunotherapy ef...

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Bibliographic Details
Main Authors: Xu Yang, Baofeng Lian, Nan Zhang, Junyu Long, Yiran Li, Jingnan Xue, Xiangqi Chen, Yunchao Wang, Yanyu Wang, Ziyu Xun, Mingjian Piao, Chenpei Zhu, Shanshan Wang, Huishan Sun, Zhijian Song, Leilei Lu, Xiaowei Dong, Aodi Wang, Wenjin Liu, Jie Pan, Xiaorong Hou, Mei Guan, Li Huo, Jie Shi, Haohai Zhang, Jinxue Zhou, Zhenhui Lu, Yilei Mao, Xinting Sang, Liqun Wu, Xiaobo Yang, Kai Wang, Haitao Zhao
Format: Article
Language:English
Published: BMC 2024-01-01
Series:BMC Medicine
Subjects:
Microsatellite instability-high
Cholangiocarcinoma
PD-1 inhibitor
PD-L1 expression
Tumor mutation burden
Overall survival
Online Access:https://doi.org/10.1186/s12916-024-03257-7

Internet

https://doi.org/10.1186/s12916-024-03257-7

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