Endotoxin- and ATP-neutralizing activity of alkaline phosphatase as a strategy to limit neuroinflammation

Endotoxin- and ATP-neutralizing activity of alkaline phosphatase as a strategy to limit neuroinflammation

<p>Abstract</p> <p>Background</p> <p>Alkaline phosphatase (AP) is a ubiquitously expressed enzyme which can neutralize endotoxin as well as adenosine triphosphate (ATP), an endogenous danger signal released during brain injury. In this study we assessed a potential ther...

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Bibliographic Details
Main Authors: Huizinga Ruth, Kreft Karim L, Onderwater Sabina, Boonstra Joke G, Brands Ruud, Hintzen Rogier Q, Laman Jon D
Format: Article
Language:English
Published: BMC 2012-12-01
Series:Journal of Neuroinflammation
Subjects:
Autoimmunity
Neuroimmunology
Lipopolysaccharide (LPS)
Purinergic signalling
Multiple sclerosis
Online Access:http://www.jneuroinflammation.com/content/9/1/266

Internet

http://www.jneuroinflammation.com/content/9/1/266

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