The ventilatory depressant actions but not the antinociceptive effects of morphine are blunted in rats receiving intravenous infusion of L-cysteine ethyl ester

The ventilatory depressant actions but not the antinociceptive effects of morphine are blunted in rats receiving intravenous infusion of L-cysteine ethyl ester

This study demonstrates that intravenous infusion of the cell-penetrant thiol ester, L-cysteine ethyl ester (L-CYSee), to adult male Sprague-Dawley rats elicited (a) minor alterations in frequency of breathing, expiratory time, tidal volume, minute ventilation, or expiratory drive but pronounced cha...

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Bibliographic Details
Main Authors: Tristan H.J. Lewis, Walter J. May, Alex P. Young, James N. Bates, Santhosh M. Baby, Paulina M. Getsy, Rita M. Ryan, Yee-Hsee Hsieh, James M. Seckler, Stephen J. Lewis
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:Biomedicine & Pharmacotherapy
Subjects:
L-thiol ester infusion
Morphine
Ventilatory depression
Arterial blood-gas chemistry
Analgesia
Sprague-Dawley rats
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332222013282

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http://www.sciencedirect.com/science/article/pii/S0753332222013282

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