In utero arsenic exposure increases DNA damage and gene expression changes in umbilical cord mesenchymal stem cells (UC-MSCs) from newborns as well as in UC-MSC differentiated hepatocytes

In utero arsenic exposure increases DNA damage and gene expression changes in umbilical cord mesenchymal stem cells (UC-MSCs) from newborns as well as in UC-MSC differentiated hepatocytes

Prenatal exposure to arsenic is associated with an increased risk of disease development such as liver cancer in adulthood. Increasing evidence suggests that fetal stem cells are key targets during transplacental chemical exposure. Our earlier study reported that in utero arsenic exposure caused var...

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Bibliographic Details
Main Authors: Siriwan Kantisin, Krittinee Chaisatra, Potchanee Hunsonti, Varabhorn Parnlob, Panida Navasumrit, Mathuros Ruchirawat
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Toxicology Reports
Subjects:
Arsenic
In utero exposure
8-OHdG
8-nitroguanine
Mesenchymal stem cells
Online Access:http://www.sciencedirect.com/science/article/pii/S2214750022001858

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http://www.sciencedirect.com/science/article/pii/S2214750022001858

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