Age-dependent alterations in neuronal activity in the hippocampus and visual cortex in a mouse model of Juvenile Neuronal Ceroid Lipofuscinosis (CLN3)

Age-dependent alterations in neuronal activity in the hippocampus and visual cortex in a mouse model of Juvenile Neuronal Ceroid Lipofuscinosis (CLN3)

Juvenile Neuronal Ceroid Lipofuscinosis (JNCL) is a fatal lysosomal storage disease caused by autosomal recessive mutations in CLN3. JNCL is typified by progressive neurodegeneration that has been suggested to occur from excessive excitatory and impaired inhibitory synaptic input; however, no studie...

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Bibliographic Details
Main Authors: Maria Burkovetskaya, Nikolay Karpuk, Tammy Kielian
Format: Article
Language:English
Published: Elsevier 2017-04-01
Series:Neurobiology of Disease
Subjects:
CLN3
Juvenile Batten disease
Neuron
Electrophysiology
Field potential
Hippocampus
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996116303126

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http://www.sciencedirect.com/science/article/pii/S0969996116303126

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