Inactivation of the CRL4-CDT2-SET8/p21 ubiquitylation and degradation axis underlies the therapeutic efficacy of pevonedistat in melanoma

Inactivation of the CRL4-CDT2-SET8/p21 ubiquitylation and degradation axis underlies the therapeutic efficacy of pevonedistat in melanoma

The cullin-based CRL4-CDT2 ubiquitin ligase is emerging as a master regulator of cell proliferation. CRL4-CDT2 prevents re-initiation of DNA replication during the same cell cycle “rereplication” through targeted degradation of CDT1, SET8 and p21 during S-phase of the cell cycle. We show that CDT2 i...

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Bibliographic Details
Main Authors: Mouadh Benamar, Fadila Guessous, Kangping Du, Patrick Corbett, Joseph Obeid, Daniel Gioeli, Craig L. Slingluff Jr, Tarek Abbas
Format: Article
Language:English
Published: Elsevier 2016-08-01
Series:EBioMedicine
Subjects:
Melanoma
CDT2
DTL
Cullin
Ubiquitylation
MLN4924
Pevonedistat
BRAF
NRAS
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396416302791

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http://www.sciencedirect.com/science/article/pii/S2352396416302791

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