Excess BAFF Alters NR4As Expression Levels and Breg Function of Human Precursor-like Marginal Zone B-Cells in the Context of HIV-1 Infection

Excess BAFF Alters NR4As Expression Levels and Breg Function of Human Precursor-like Marginal Zone B-Cells in the Context of HIV-1 Infection

We have reported excess B-cell activating factor (BAFF) in the blood of HIV-infected progressors, which was concomitant with increased frequencies of precursor-like marginal zone (MZp) B-cells, early on and despite antiretroviral therapy (ART). In controls, MZp possess a strong B-cell regulatory (Br...

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Bibliographic Details
Main Authors: Kim Doyon-Laliberté, Matheus Aranguren, Michelle Byrns, Josiane Chagnon-Choquet, Matteo Paniconi, Jean-Pierre Routy, Cécile Tremblay, Marie-Claude Quintal, Nathalie Brassard, Daniel E. Kaufmann, Johanne Poudrier, Michel Roger
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:International Journal of Molecular Sciences
Subjects:
HIV
Breg
NR4A
MZp
BAFF
Online Access:https://www.mdpi.com/1422-0067/23/23/15142

Internet

https://www.mdpi.com/1422-0067/23/23/15142

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