Identification of differentially recognized T cell epitopes in the spectrum of tuberculosis infection

Identification of differentially recognized T cell epitopes in the spectrum of tuberculosis infection

Abstract There is still incomplete knowledge of which Mycobacterium tuberculosis (Mtb) antigens can trigger distinct T cell responses at different stages of infection. Here, a proteome-wide screen of 20,610 Mtb-derived peptides in 21 patients mid-treatment for active tuberculosis (ATB) reveals IFNγ-...

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Bibliographic Details
Main Authors: Sudhasini Panda, Jeffrey Morgan, Catherine Cheng, Mayuko Saito, Robert H. Gilman, Nelly Ciobanu, Valeriu Crudu, Donald G. Catanzaro, Antonino Catanzaro, Timothy Rodwell, Judy S. B. Perera, Teshan Chathuranga, Bandu Gunasena, Aruna D. DeSilva, Bjoern Peters, Alessandro Sette, Cecilia S. Lindestam Arlehamn
Format: Article
Language:English
Published: Nature Portfolio 2024-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-45058-9

Internet

https://doi.org/10.1038/s41467-024-45058-9

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