Polymer-Functionalized Mitochondrial Transplantation to Fibroblasts Counteracts a Pro-Fibrotic Phenotype

Polymer-Functionalized Mitochondrial Transplantation to Fibroblasts Counteracts a Pro-Fibrotic Phenotype

Fibroblast-to-myofibroblast transition (FMT) leads to excessive extracellular matrix (ECM) deposition—a well-known hallmark of fibrotic disease. Transforming growth factor-β (TGF-β) is the primary cytokine driving FMT, and this phenotypic conversion is associated with mitochondrial dysfunction, nota...

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Bibliographic Details
Main Authors: Gherardo Baudo, Suhong Wu, Matteo Massaro, Haoran Liu, Hyunho Lee, Aijun Zhang, Dale J. Hamilton, Elvin Blanco
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:International Journal of Molecular Sciences
Subjects:
mitochondrial transplantation
fibroblasts
transforming growth factor-β
fibroblast-to-myofibroblast transition
glycolysis
Online Access:https://www.mdpi.com/1422-0067/24/13/10913

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https://www.mdpi.com/1422-0067/24/13/10913

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