9-PAHSA displays a weak anti-inflammatory potential mediated by specific antagonism of chemokine G protein-coupled receptors

9-PAHSA displays a weak anti-inflammatory potential mediated by specific antagonism of chemokine G protein-coupled receptors

Introduction: 9-PAHSA belongs to a class of endogenous mammalian bioactive lipids, fatty acid esters of hydroxy fatty acids (FAHFA), that are present in circulation at nanomolar concentrations in mice and humans. Published preclinical data suggest beneficial effects of 9-PAHSA treatment on glucose m...

Full description

Bibliographic Details
Main Authors: Paulus Wohlfart, Mounir Chehtane, Ernesto Luna, Riyaz Mehta, Marcus Korn, Anish Konkar, Uwe Schwahn, Stefan Petry, Norbert Tennagels, Maximilian Bielohuby
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-07-01
Series:Frontiers in Drug Discovery
Subjects:
receptors/ seven transmembrane domain
cell signaling
inflammation
obesity
cytokines
fatty acids
Online Access:https://www.frontiersin.org/articles/10.3389/fddsv.2023.1138461/full

Internet

https://www.frontiersin.org/articles/10.3389/fddsv.2023.1138461/full

Similar Items