Targeting ROCK1 in diabetic kidney disease: Unraveling mesangial fibrosis mechanisms and introducing myricetin as a novel antagonist

Targeting ROCK1 in diabetic kidney disease: Unraveling mesangial fibrosis mechanisms and introducing myricetin as a novel antagonist

Diabetic kidney disease (DKD) stands as a pressing health challenge, with mesangial cell fibrosis identified as a pivotal hallmark leading to glomerular sclerosis. Gaining a deeper grasp on the molecular dynamics behind this can potentially introduce groundbreaking therapeutic avenues. Recent revela...

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Bibliographic Details
Main Authors: Ningning Yuan, Jianxin Diao, Jiamei Dong, Yangtian Yan, Yuchi Chen, Shihua Yan, Changshun Liu, Zhuoen He, Jinyue He, Chi Zhang, Hao Wang, Mingqing Wang, Fei He, Wei Xiao
Format: Article
Language:English
Published: Elsevier 2024-02-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Diabetic kidney disease
Mesangial cells
Fibrosis
ROCK1
Myricetin
Docking screening
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332224000891

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http://www.sciencedirect.com/science/article/pii/S0753332224000891

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