Data-independent acquisition proteomic analysis of the brain microvasculature in Alzheimer’s disease identifies major pathways of dysfunction and upregulation of cytoprotective responses

Data-independent acquisition proteomic analysis of the brain microvasculature in Alzheimer’s disease identifies major pathways of dysfunction and upregulation of cytoprotective responses

Abstract Brain microvascular dysfunction is an important feature of Alzheimer’s disease (AD). To better understand the brain microvascular molecular signatures of AD, we processed and analyzed isolated human brain microvessels by data-independent acquisition liquid chromatography with tandem mass sp...

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Bibliographic Details
Main Authors: Michelle A. Erickson, Richard S. Johnson, Mamatha Damodarasamy, Michael J. MacCoss, C. Dirk Keene, William A. Banks, May J. Reed
Format: Article
Language:English
Published: BMC 2024-10-01
Series:Fluids and Barriers of the CNS
Subjects:
Alzheimer’s disease
Blood–brain barrier
Brain microvessels
Neurovascular unit
Proteomics
Online Access:https://doi.org/10.1186/s12987-024-00581-1

Internet

https://doi.org/10.1186/s12987-024-00581-1

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