Degradation of methylation signals in cryopreserved DNA

Degradation of methylation signals in cryopreserved DNA

Abstract Background Blood-based DNA methylation has shown great promise as a biomarker in a wide variety of diseases. Studies of DNA methylation in blood often utilize samples which have been cryopreserved for years or even decades. Therefore, changes in DNA methylation associated with long-term cry...

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Bibliographic Details
Main Authors: Ning Yuan Lee, Melissa Hum, Guek Peng Tan, Ai Choo Seah, Patricia T. Kin, Ngiap Chuan Tan, Hai-Yang Law, Ann S. G. Lee
Format: Article
Language:English
Published: BMC 2023-09-01
Series:Clinical Epigenetics
Subjects:
Methylation
Blood
Cryopreservation
Storage
Buffy coat
DNA
Online Access:https://doi.org/10.1186/s13148-023-01565-y

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