Simvastatin Sodium Salt and Fluvastatin Interact with Human Gap Junction Gamma-3 Protein.

Simvastatin Sodium Salt and Fluvastatin Interact with Human Gap Junction Gamma-3 Protein.

Finding pleiomorphic targets for drugs allows new indications or warnings for treatment to be identified. As test of concept, we applied a new chemical genomics approach to uncover additional targets for the widely prescribed lipid-lowering pro-drug simvastatin. We used mRNA extracted from internal...

Full description

Bibliographic Details
Main Authors:	Andrew Marsh, Katherine Casey-Green, Fay Probert, David Withall, Daniel A Mitchell, Suzanne J Dilly, Sean James, Wade Dimitri, Sweta R Ladwa, Paul C Taylor, Donald R J Singer
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2016-01-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC4749215?pdf=render

Similar Items

Evaluate the efficacy of Simvastatin and Fluvastatin in patients with hypercholesterolemia and their effect on liver functions
by: Hassan A. H. Ali, et al.
Published: (2017-12-01)

Simvastatin and fluvastatin attenuate trauma-induced cell death and catabolism in human cartilage
by: Jana Riegger, et al.
Published: (2022-09-01)

New HPLC method for determination of fluvastatin anti-hyperlipidemic drug in bulk and pharmaceutical dosage using simvastatin as internal standard
by: Safwan Ashour, et al.
Published: (2023-07-01)

Genetic analysis of fluvastatin response and dyslipidemia in renal transplant recipientss⃞
by: Jonathan B. Singer, et al.
Published: (2007-09-01)

Binding of β-casein with fluvastatin and pitavastatin
by: Dezhampanah Hamid, et al.
Published: (2022-01-01)

Rhabdomyolysis induced by co-administration of fluvastatin and colchicine
by: Filippo M. Sarullo, et al.
Published: (2015-12-01)

Improvement of fluvastatin bioavailability by loading on nanostructured lipid carriers
by: El-Helw AR, et al.
Published: (2015-09-01)

Fluvastatin for reduction of cardiovascular risk in patients with moderate to severe renal insufficiency.
by: Haynes, R, et al.
Published: (2007)

A COMPARISON BETWEEN FLUVASTATIN AND LOVASTATIN EFFECTS IN IRANIAN PATIENTS WITH HYPERCHOLESTEROLEMIA
by: S. Moradm, et al.
Published: (1998-12-01)

A COMPARISON BETWEEN FLUVASTATIN AND LOVASTATIN EFFECTS IN IRANIAN PATIENTS WITH HYPERCHOLESTEROLEMIA
by: S. Moradm, et al.
Published: (1998-08-01)

Synergistic Effect Of Simvastatin And Romidepsin On Gamma-Globin Gene Induction
by: Hussain Habibi, et al.
Published: (2018-08-01)

Gene signature associated with resistance to fluvastatin chemoprevention for breast cancer
by: Anjana Bhardwaj, et al.
Published: (2022-03-01)

Fluvastatin Prevents Lung Adenocarcinoma Bone Metastasis by Triggering Autophagy
by: Zuozhang Yang, et al.
Published: (2017-05-01)

Synthesis and biological evaluation of novel β-cyclodextrin-fluvastatin conjugates
by: Mariacristina Nicolosi, et al.
Published: (2021-01-01)

Enhanced oral bioavailability of fluvastatin by using nanosuspensions containing cyclodextrin
by: Li J, et al.
Published: (2018-10-01)

EFFECTS OF THERAPY ON THE ABILITY OF ERYTHROCYTES FLUVASTATIN AGGREGATION IN HYPERTENSIVE PATIENTS WITH DYSLIPIDEMIA
by: I. N. Medvedev, et al.
Published: (2012-03-01)

FLUVASTATIN EFFECTS ON BLOOD CELL AGGREGATION IN PATIENTS WITH ARTERIAL HYPERTENSION AND DYSLIPIDEMIA
by: I. N. Medvedev, et al.
Published: (2013-04-01)

Simple UV Spectrophotometric Method for the Determination of Fluvastatin Sodium in Bulk and Pharmaceutical Formulations
by: J. Saminathan, et al.
Published: (2009-01-01)

Effects of fluvastatin, valsartan, and their combination on endothelial function in patients with arterial hypertension and dyslipidemia
by: T. Sh. Mirilashvili, et al.
Published: (2009-08-01)

Role of Fluvastatin sodium loaded polymeric nanoparticles in the treatment of Hyperlipidemia: Fabrication and Characterization
by: Avinash S Gudigennavar, et al.
Published: (2023-01-01)

Development and validation of a GC-FID assay for determination of fluvastatin in pharmaceutical preparations
by: Serap Saglik Aslan, et al.
Published: (2009-01-01)

Detrimental effects of fluvastatin on plasma lipid metabolism in rat breast carcinoma model
by: Kapinová Andrea, et al.
Published: (2013-01-01)

Potential therapeutic effect of thymoquinone and/or bee pollen on fluvastatin-induced hepatitis in rats
by: Amro E. Mohamed, et al.
Published: (2021-08-01)

Fluvastatin and Vascular Endothelial Growth Factor-Containing Resins Promote Angiogenesis and Arteriogenesis
by: Furqan Muqri, et al.
Published: (2020-01-01)

Inhibition of Orbivirus Replication by Fluvastatin and Identification of the Key Elements of the Mevalonate Pathway Involved
by: Fauziah Mohd Jaafar, et al.
Published: (2021-07-01)

Fluvastatin Promotes Treg Cell Production in Allogeneic Immune Reaction and Suppresses Inflammatory Response
by: Xianxian Chen, et al.
Published: (2025-02-01)

Dynamics of clinical, functional, and immune parameters in patients with myocardial infarction and early fluvastatin administration
by: V. V. Belov, et al.
Published: (2011-08-01)

Atorvastatin and Fluvastatin Potentiate Blood Pressure Lowering Effect of Amlodipine through Vasorelaxant Phenomenon
by: Niaz Ali, et al.
Published: (2023-05-01)

Effects of Fluvastatin on Characteristics of Stellate Ganglion Neurons in a Rabbit Model of Myocardial Ischemia
by: Li-Jun Cheng, et al.
Published: (2016-01-01)

Hypercholesterolemia in Renal Transplant Recipients; contributing Factors, Effect of Dietary Modification and Fluvastatin Therapy
by: Rahed Awad, et al.
Published: (1999-01-01)

The influence of genetic polymorphisms in drug metabolism enzymes and transporters on the pharmacokinetics of different fluvastatin formulations
by: Qian Xiang, et al.
Published: (2020-03-01)

Modulation of Ion Channels in the Superior Cervical Ganglion Neurons by Myocardial Ischemia and Fluvastatin Treatment
by: Lijun Cheng, et al.
Published: (2018-09-01)

Beneficial effect of simvastatin on human umbilical vein endothelial cells gap junctions induced by TNF-α
by: Xiwen Ling, et al.
Published: (2022-01-01)

Fasting levels of growth hormone are associated with carotid intima media thickness but are not affected by fluvastatin treatment
by: Erik Hallengren, et al.
Published: (2017-05-01)

Fluvastatin use and risk of acute pancreatitis: a population-based case-control study in Taiwan
by: Liao Kuan-Fu, et al.
Published: (2017-09-01)

Fluvastatin Reduces Glucose Tolerance in Healthy Young Individuals Independently of Cold Induced BAT Activity
by: Martina Felder, et al.
Published: (2021-11-01)

Regulation of Autophagy Progress via Lysosomal Depletion by Fluvastatin Nanoparticle Treatment in Breast Cancer Cells
by: Hanan Elimam, et al.
Published: (2020-06-01)

Efeitos da atorvastatina, fluvastatina, pravastatina e simvastatina sobre a função endotelial, a peroxidação lipídica e a aterosclerose aórtica em coelhos hipercolesterolêmicos Effects of atorvastatin, fluvastatin, pravastatin, and simvastatin on endothelial function, lipid peroxidation, and aortic atherosclerosis in hypercholesterolemic rabbits
by: Paulo Afonso Ribeiro Jorge, et al.
Published: (2005-04-01)

Hybrid nanoparticulate system of Fluvastatin loaded phospholipid, alpha lipoic acid and melittin for the management of colon cancer
by: Alfaleh, Mohamed A., et al.
Published: (2022)

Fluvastatin increases tyrosinase synthesis induced by UVB irradiation of B16F10 melanoma cells.
by: Krzysztof Włodarski, et al.
Published: (2010-02-01)