Altered coronary artery function, arteriogenesis and endothelial YAP signaling in postnatal hypertrophic cardiomyopathy

Altered coronary artery function, arteriogenesis and endothelial YAP signaling in postnatal hypertrophic cardiomyopathy

Introduction: Hypertrophic cardiomyopathy (HCM) is a cardiovascular genetic disease caused largely by sarcomere protein mutations. Gaps in our understanding exist as to how maladaptive sarcomeric biophysical signals are transduced to intra- and extracellular compartments leading to HCM progression....

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Bibliographic Details
Main Authors: Paulina Langa, Richard J. Marszalek, Chad M. Warren, Shamim K. Chowdhury, Monika Halas, Ashley Batra, Koreena Rafael-Clyke, Angelie Bacon, Paul H. Goldspink, R. John Solaro, Beata M. Wolska
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Physiology
Subjects:
hypertrophic cardiomyopathy
YAP signaling
mechano-signaling
coronary flow
echocardiography
fibrosis
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2023.1136852/full

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https://www.frontiersin.org/articles/10.3389/fphys.2023.1136852/full

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