Biological and pharmacological functions of the FGF19- and FGF21-coreceptor beta klotho

Biological and pharmacological functions of the FGF19- and FGF21-coreceptor beta klotho

Beta klotho (KLB) is a fundamental component in fibroblast growth factor receptor (FGFR) signaling as it serves as an obligatory coreceptor for the endocrine hormones fibroblast growth factor 19 (FGF19) and fibroblast growth factor 21 (FGF21). Through the development of FGF19- and FGF21 mimetics, KL...

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Bibliographic Details
Main Authors: Alexandra S. Aaldijk, Cristy R. C. Verzijl, Johan W. Jonker, Dicky Struik
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Endocrinology
Subjects:
beta klotho
FGF19
FGF21
FGFR
NAFLD
NASH
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2023.1150222/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2023.1150222/full

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