Consequences of GMPPB deficiency for neuromuscular development and maintenance

Consequences of GMPPB deficiency for neuromuscular development and maintenance

Guanosine diphosphate-mannose pyrophosphorylase B (GMPPB) catalyzes the conversion of mannose-1-phosphate and GTP to GDP-mannose, which is required as a mannose donor for the biosynthesis of glycan structures necessary for proper cellular functions. Mutations in GMPPB have been associated with vario...

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Bibliographic Details
Main Authors: Mona K. Schurig, Obinna Umeh, Henriette Henze, M. Juliane Jung, Lennart Gresing, Véronique Blanchard, Julia von Maltzahn, Christian A. Hübner, Patricia Franzka
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-02-01
Series:Frontiers in Molecular Neuroscience
Subjects:
glycosylation
mannosylation
GMPPB
skeletal muscle
nervous system
myogenesis
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2024.1356326/full

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https://www.frontiersin.org/articles/10.3389/fnmol.2024.1356326/full

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