Structure of the catalytic domain of EZH2 reveals conformational plasticity in cofactor and substrate binding sites and explains oncogenic mutations.

Structure of the catalytic domain of EZH2 reveals conformational plasticity in cofactor and substrate binding sites and explains oncogenic mutations.

Polycomb repressive complex 2 (PRC2) is an important regulator of cellular differentiation and cell type identity. Overexpression or activating mutations of EZH2, the catalytic component of the PRC2 complex, are linked to hyper-trimethylation of lysine 27 of histone H3 (H3K27me3) in many cancers. Po...

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Bibliographic Details
Main Authors: Hong Wu, Hong Zeng, Aiping Dong, Fengling Li, Hao He, Guillermo Senisterra, Alma Seitova, Shili Duan, Peter J Brown, Masoud Vedadi, Cheryl H Arrowsmith, Matthieu Schapira
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3868588?pdf=render

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http://europepmc.org/articles/PMC3868588?pdf=render

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