An FGF15/19-TFEB regulatory loop controls hepatic cholesterol and bile acid homeostasis

An FGF15/19-TFEB regulatory loop controls hepatic cholesterol and bile acid homeostasis

TFEB is a transcriptional regulator of lysosomal biogenesis, activated upon starvation or lysosomal stress. Here the authors report that TFEB regulates hepatic bile acid synthesis downstream of FGF19 signaling.

Bibliographic Details
Main Authors: Yifeng Wang, Sumedha Gunewardena, Feng Li, David J. Matye, Cheng Chen, Xiaojuan Chao, Taeyoon Jung, Yuxia Zhang, Maciej Czerwiński, Hong-Min Ni, Wen-Xing Ding, Tiangang Li
Format: Article
Language:English
Published: Nature Portfolio 2020-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-17363-6

Internet

https://doi.org/10.1038/s41467-020-17363-6

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