An FGF15/19-TFEB regulatory loop controls hepatic cholesterol and bile acid homeostasis
TFEB is a transcriptional regulator of lysosomal biogenesis, activated upon starvation or lysosomal stress. Here the authors report that TFEB regulates hepatic bile acid synthesis downstream of FGF19 signaling.
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2020-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-17363-6 |
| _version_ | 1818344115795918848 |
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| author | Yifeng Wang Sumedha Gunewardena Feng Li David J. Matye Cheng Chen Xiaojuan Chao Taeyoon Jung Yuxia Zhang Maciej Czerwiński Hong-Min Ni Wen-Xing Ding Tiangang Li |
| author_facet | Yifeng Wang Sumedha Gunewardena Feng Li David J. Matye Cheng Chen Xiaojuan Chao Taeyoon Jung Yuxia Zhang Maciej Czerwiński Hong-Min Ni Wen-Xing Ding Tiangang Li |
| author_sort | Yifeng Wang |
| collection | DOAJ |
| description | TFEB is a transcriptional regulator of lysosomal biogenesis, activated upon starvation or lysosomal stress. Here the authors report that TFEB regulates hepatic bile acid synthesis downstream of FGF19 signaling. |
| first_indexed | 2024-12-13T16:41:21Z |
| format | Article |
| id | doaj.art-e9a63e08c6d4478bbf30ac94313ec4ce |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-13T16:41:21Z |
| publishDate | 2020-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-e9a63e08c6d4478bbf30ac94313ec4ce2022-12-21T23:38:16ZengNature PortfolioNature Communications2041-17232020-07-0111111610.1038/s41467-020-17363-6An FGF15/19-TFEB regulatory loop controls hepatic cholesterol and bile acid homeostasisYifeng Wang0Sumedha Gunewardena1Feng Li2David J. Matye3Cheng Chen4Xiaojuan Chao5Taeyoon Jung6Yuxia Zhang7Maciej Czerwiński8Hong-Min Ni9Wen-Xing Ding10Tiangang Li11Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical CenterDepartment of Molecular and Integrative Physiology, University of Kansas Medical CenterDepartment of Molecular and Cellular Biology, Baylor College of MedicineDepartment of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical CenterDepartment of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical CenterDepartment of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical CenterDepartment of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical CenterDepartment of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical CenterSekisui XenoTech LLCDepartment of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical CenterDepartment of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical CenterHarold Hamm Diabetes Center, Department of Physiology, University of Oklahoma Health Sciences CenterTFEB is a transcriptional regulator of lysosomal biogenesis, activated upon starvation or lysosomal stress. Here the authors report that TFEB regulates hepatic bile acid synthesis downstream of FGF19 signaling.https://doi.org/10.1038/s41467-020-17363-6 |
| spellingShingle | Yifeng Wang Sumedha Gunewardena Feng Li David J. Matye Cheng Chen Xiaojuan Chao Taeyoon Jung Yuxia Zhang Maciej Czerwiński Hong-Min Ni Wen-Xing Ding Tiangang Li An FGF15/19-TFEB regulatory loop controls hepatic cholesterol and bile acid homeostasis Nature Communications |
| title | An FGF15/19-TFEB regulatory loop controls hepatic cholesterol and bile acid homeostasis |
| title_full | An FGF15/19-TFEB regulatory loop controls hepatic cholesterol and bile acid homeostasis |
| title_fullStr | An FGF15/19-TFEB regulatory loop controls hepatic cholesterol and bile acid homeostasis |
| title_full_unstemmed | An FGF15/19-TFEB regulatory loop controls hepatic cholesterol and bile acid homeostasis |
| title_short | An FGF15/19-TFEB regulatory loop controls hepatic cholesterol and bile acid homeostasis |
| title_sort | fgf15 19 tfeb regulatory loop controls hepatic cholesterol and bile acid homeostasis |
| url | https://doi.org/10.1038/s41467-020-17363-6 |
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