Sequence- and structure-specific RNA oligonucleotide binding attenuates heterogeneous nuclear ribonucleoprotein A1 dysfunction

Sequence- and structure-specific RNA oligonucleotide binding attenuates heterogeneous nuclear ribonucleoprotein A1 dysfunction

The RNA binding protein heterogeneous nuclear ribonucleoprotein A1 (A1) regulates RNA metabolism, which is crucial to maintaining cellular homeostasis. A1 dysfunction mechanistically contributes to reduced cell viability and loss, but molecular mechanisms of how A1 dysfunction affects cell viability...

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Bibliographic Details
Main Authors: Joseph P. Clarke, Patricia A. Thibault, Sakina Fatima, Hannah E. Salapa, Subha Kalyaanamoorthy, Aravindhan Ganesan, Michael C. Levin
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Molecular Biosciences
Subjects:
hnRNPA1
RNA oligonucleotide
optogenetics
stress granules
RNA-protein interaction
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2023.1178439/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2023.1178439/full

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