Vitamin C boosts DNA demethylation in TET2 germline mutation carriers

Vitamin C boosts DNA demethylation in TET2 germline mutation carriers

Abstract Background Accurate regulation of DNA methylation is necessary for normal cells to differentiate, develop and function. TET2 catalyzes stepwise DNA demethylation in hematopoietic cells. Mutations in the TET2 gene predispose to hematological malignancies by causing DNA methylation overload a...

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Bibliographic Details
Main Authors: Aurora Taira, Kimmo Palin, Anna Kuosmanen, Niko Välimäki, Outi Kuittinen, Outi Kuismin, Eevi Kaasinen, Kristiina Rajamäki, Lauri A. Aaltonen
Format: Article
Language:English
Published: BMC 2023-01-01
Series:Clinical Epigenetics
Subjects:
DNA methylation
TET2 mutations
Vitamin C
Hematological neoplasia
Online Access:https://doi.org/10.1186/s13148-022-01404-6

Internet

https://doi.org/10.1186/s13148-022-01404-6

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