The Influence of Structural Variants of the <i>CES1</i> Gene on the Pharmacokinetics of Enalapril, Presumably Due to Linkage Disequilibrium with the Intronic rs2244613

The Influence of Structural Variants of the <i>CES1</i> Gene on the Pharmacokinetics of Enalapril, Presumably Due to Linkage Disequilibrium with the Intronic rs2244613

Variants in the <i>CES1</i> gene encoding carboxylesterase 1 may affect the metabolism of enalapril to the active metabolite enalaprilat. It was shown that the A allele of rs71647871 and the C allele of rs2244613 led to a decrease in plasma enalaprilat concentrations. This study aimed to...

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Bibliographic Details
Main Authors: Anna Ikonnikova, Ruslan Kazakov, Tatiana Rodina, Artem Dmitriev, Evgeniy Melnikov, Alexander Zasedatelev, Tatiana Nasedkina
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Genes
Subjects:
carboxylesterase 1
<i>CES1</i>
<i>CES1P1</i>
<i>CES1A2</i>
rs2244613
enalapril
Online Access:https://www.mdpi.com/2073-4425/13/12/2225

Internet

https://www.mdpi.com/2073-4425/13/12/2225

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