Chagas Disease Megaesophagus Patients Carrying Variant <i>MRPS18B</i> P260A Display Nitro-Oxidative Stress and Mitochondrial Dysfunction in Response to IFN-γ Stimulus

Chagas Disease Megaesophagus Patients Carrying Variant <i>MRPS18B</i> P260A Display Nitro-Oxidative Stress and Mitochondrial Dysfunction in Response to IFN-γ Stimulus

Chagas disease (CD), caused by the protozoan parasite <i>Trypanosoma cruzi</i>, affects 8 million people, and around 1/3 develop chronic cardiac (CCC) or digestive disease (megaesophagus/megacolon), while the majority remain asymptomatic, in the indeterminate form of Chagas disease (ASY)...

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Bibliographic Details
Main Authors: Karla Deysiree Alcântara Silva, João Paulo Silva Nunes, Pauline Andrieux, Pauline Brochet, Rafael Ribeiro Almeida, Andréia Cristina Kazue Kuramoto Takara, Natalia Bueno Pereira, Laurent Abel, Aurelie Cobat, Ricardo Costa Fernandes Zaniratto, Débora Levy, Sergio Paulo Bydlowski, Ivan Cecconello, Francisco Carlos Bernal da Costa Seguro, Jorge Kalil, Christophe Chevillard, Edecio Cunha-Neto
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Biomedicines
Subjects:
chagasic megaesophagus
mitochondria
mitochondrial mutation
mitochondrial dysfunction
interferon-gamma
MRPS18B
Online Access:https://www.mdpi.com/2227-9059/10/9/2215

Internet

https://www.mdpi.com/2227-9059/10/9/2215

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