Dual Induction of New Microbial Secondary Metabolites by Fungal Bacterial Co-cultivation

The frequent re-isolation of known compounds is one of the major challenges in drug discovery. Many biosynthetic genes are not expressed under standard culture conditions, thus limiting the chemical diversity of microbial compounds that can be obtained through fermentation. On the other hand, the co...

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Bibliographic Details
Main Authors: Jennifer Wakefield, Hossam M. Hassan, Marcel Jaspars, Rainer Ebel, Mostafa E. Rateb
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-07-01
Series:Frontiers in Microbiology
Subjects:
Online Access:http://journal.frontiersin.org/article/10.3389/fmicb.2017.01284/full