Multiomic analysis on human cell model of wolfram syndrome reveals changes in mitochondrial morphology and function

Multiomic analysis on human cell model of wolfram syndrome reveals changes in mitochondrial morphology and function

Abstract Background Wolfram syndrome (WFS) is a rare autosomal recessive syndrome in which diabetes mellitus and neurodegenerative disorders occur as a result of Wolframin deficiency and increased ER stress. In addition, WFS1 deficiency leads to calcium homeostasis disturbances and can change mitoch...

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Bibliographic Details
Main Authors: Agnieszka Zmyslowska, Miljan Kuljanin, Beata Malachowska, Marcin Stanczak, Dominika Michalek, Aneta Wlodarczyk, Dagmara Grot, Joanna Taha, Bartłomiej Pawlik, Magdalena Lebiedzińska-Arciszewska, Hanna Nieznanska, Mariusz R. Wieckowski, Piotr Rieske, Joseph D. Mancias, Maciej Borowiec, Wojciech Mlynarski, Wojciech Fendler
Format: Article
Language:English
Published: BMC 2021-11-01
Series:Cell Communication and Signaling
Subjects:
Wolfram syndrome
Proteomics
Transcriptomics
Mitochondria
ER stress
Online Access:https://doi.org/10.1186/s12964-021-00791-2

Internet

https://doi.org/10.1186/s12964-021-00791-2

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