Modulation of Hypoxia-Induced Chemoresistance to Polymeric Micellar Cisplatin: The Effect of Ligand Modification of Micellar Carrier Versus Inhibition of the Mediators of Drug Resistance

Modulation of Hypoxia-Induced Chemoresistance to Polymeric Micellar Cisplatin: The Effect of Ligand Modification of Micellar Carrier Versus Inhibition of the Mediators of Drug Resistance

Hypoxia can induce chemoresistance, which is a significant clinical obstacle in cancer therapy. Here, we assessed development of hypoxia-induced chemoresistance (HICR) against free versus polymeric cisplatin micelles in a triple negative breast cancer cell line, MDA-MB-231. We then explored two stra...

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Bibliographic Details
Main Authors: Hoda Soleymani Abyaneh, Amir Hassan Soleimani, Mohammad Reza Vakili, Rania Soudy, Kamaljit Kaur, Francesco Cuda, Ali Tavassoli, Afsaneh Lavasanifar
Format: Article
Language:English
Published: MDPI AG 2018-10-01
Series:Pharmaceutics
Subjects:
hypoxia-induced chemoresistance
cisplatin
polymeric micelle
EGFR-targeted therapy
STAT3
HIF-1
GE11 peptide
pharmacological Inhibitors of HIF-1 and STAT3
combination therapy
Online Access:http://www.mdpi.com/1999-4923/10/4/196

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http://www.mdpi.com/1999-4923/10/4/196

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