DNA Damage Regulates Senescence-Associated Extracellular Vesicle Release via the Ceramide Pathway to Prevent Excessive Inflammatory Responses

DNA Damage Regulates Senescence-Associated Extracellular Vesicle Release via the Ceramide Pathway to Prevent Excessive Inflammatory Responses

DNA damage, caused by various oncogenic stresses, can induce cell death or cellular senescence as an important tumor suppressor mechanism. Senescent cells display the features of a senescence-associated secretory phenotype (SASP), secreting inflammatory proteins into surrounding tissues, and contrib...

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Bibliographic Details
Main Authors: Kazuhiro Hitomi, Ryo Okada, Tze Mun Loo, Kenichi Miyata, Asako J. Nakamura, Akiko Takahashi
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:International Journal of Molecular Sciences
Subjects:
DNA damage
extracellular vesicle (EV)
exosome
ceramide pathway
cellular senescence
senescence-associated secretory phenotype (SASP)
Online Access:https://www.mdpi.com/1422-0067/21/10/3720

Internet

https://www.mdpi.com/1422-0067/21/10/3720

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