Regulatory analysis of single cell multiome gene expression and chromatin accessibility data with scREG

Regulatory analysis of single cell multiome gene expression and chromatin accessibility data with scREG

Abstract Technological development has enabled the profiling of gene expression and chromatin accessibility from the same cell. We develop scREG, a dimension reduction methodology, based on the concept of cis-regulatory potential, for single cell multiome data. This concept is further used for the c...

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Bibliographic Details
Main Authors: Zhana Duren, Fengge Chang, Fnu Naqing, Jingxue Xin, Qiao Liu, Wing Hung Wong
Format: Article
Language:English
Published: BMC 2022-05-01
Series:Genome Biology
Subjects:
Single cell multiome
cis-Regulatory potential
Dimension reduction
cis-Regulatory networks
Online Access:https://doi.org/10.1186/s13059-022-02682-2

Internet

https://doi.org/10.1186/s13059-022-02682-2

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