PC1/3 Deficiency Impacts Pro-opiomelanocortin Processing in Human Embryonic Stem Cell-Derived Hypothalamic Neurons

PC1/3 Deficiency Impacts Pro-opiomelanocortin Processing in Human Embryonic Stem Cell-Derived Hypothalamic Neurons

We recently developed a technique for generating hypothalamic neurons from human pluripotent stem cells. Here, as proof of principle, we examine the use of these cells in modeling of a monogenic form of severe obesity: PCSK1 deficiency. The cognate enzyme, PC1/3, processes many prohormones in neuroe...

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Bibliographic Details
Main Authors: Liheng Wang, Lina Sui, Sunil K. Panigrahi, Kana Meece, Yurong Xin, Jinrang Kim, Jesper Gromada, Claudia A. Doege, Sharon L. Wardlaw, Dieter Egli, Rudolph L. Leibel
Format: Article
Language:English
Published: Elsevier 2017-02-01
Series:Stem Cell Reports
Subjects:
PC1/3 deficiency
hESC
hypothalamic neurons
POMC processing
obesity
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671116303113

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http://www.sciencedirect.com/science/article/pii/S2213671116303113

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