Quantitative glycoproteomics reveals cellular substrate selectivity of the ER protein quality control sensors UGGT1 and UGGT2

Quantitative glycoproteomics reveals cellular substrate selectivity of the ER protein quality control sensors UGGT1 and UGGT2

UDP-glucose:glycoprotein glucosyltransferase (UGGT) 1 and 2 are central hubs in the chaperone network of the endoplasmic reticulum (ER), acting as gatekeepers to the early secretory pathway, yet little is known about their cellular clients. These two quality control sensors control lectin chaperone...

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Bibliographic Details
Main Authors: Benjamin M Adams, Nathan P Canniff, Kevin P Guay, Ida Signe Bohse Larsen, Daniel N Hebert
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-12-01
Series:eLife
Subjects:
calnexin
calreticulin
lectin chaperones
protein homeostasis
glycoproteomics
Online Access:https://elifesciences.org/articles/63997

Internet

https://elifesciences.org/articles/63997

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