Endoplasmic reticulum stress inhibition ameliorated WFS1 expression alterations and reduced pancreatic islets’ insulin secretion induced by high-fat diet in rats

Endoplasmic reticulum stress inhibition ameliorated WFS1 expression alterations and reduced pancreatic islets’ insulin secretion induced by high-fat diet in rats

Abstract Endoplasmic reticulum (ER) stress is involved in the development of glucose homeostasis impairment. When ER stress occurs, the unfolded protein response (UPR) is activated to cope with it. One of the UPR components is WFS1 (Wolfram syndrome 1), which plays important roles in ER homeostasis...

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Bibliographic Details
Main Authors: Fateme Binayi, Javad Fahanik-Babaei, Mina Salimi, Farzaneh Eskandari, Mohammad Sahraei, Ali Ghorbani Ranjbary, Rasoul Ghasemi, Mehdi Hedayati, Fariba Khodagholi, Afsaneh Eliassi, Homeira Zardooz
Format: Article
Language:English
Published: Nature Portfolio 2023-02-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-28329-1

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https://doi.org/10.1038/s41598-023-28329-1

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