ERBB3 overexpression due to miR-205 inactivation confers sensitivity to FGF, metabolic activation, and liability to ERBB3 targeting in glioblastoma

ERBB3 overexpression due to miR-205 inactivation confers sensitivity to FGF, metabolic activation, and liability to ERBB3 targeting in glioblastoma

Summary: In glioblastoma (GBM), the most frequent and lethal brain tumor, therapies suppressing recurrently altered signaling pathways failed to extend survival. However, in patient subsets, specific genetic lesions can confer sensitivity to targeted agents. By exploiting an integrated model based o...

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Bibliographic Details
Main Authors: Francesca De Bacco, Francesca Orzan, Jessica Erriquez, Elena Casanova, Ludovic Barault, Raffaella Albano, Antonio D’Ambrosio, Viola Bigatto, Gigliola Reato, Monica Patanè, Bianca Pollo, Geoffrey Kuesters, Carmine Dell’Aglio, Laura Casorzo, Serena Pellegatta, Gaetano Finocchiaro, Paolo M. Comoglio, Carla Boccaccio
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:Cell Reports
Subjects:
glioblastoma
ERBB3
HER3
miR-205
FGF
cancer stem cell
Online Access:http://www.sciencedirect.com/science/article/pii/S221112472100872X

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http://www.sciencedirect.com/science/article/pii/S221112472100872X

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