TRAIL-dependent apoptosis of peritoneal mesothelial cells by NK cells promotes ovarian cancer invasion

TRAIL-dependent apoptosis of peritoneal mesothelial cells by NK cells promotes ovarian cancer invasion

Summary: A crucial requirement for metastasis formation in ovarian high-grade serous carcinoma (HGSC) is the disruption of the protective peritoneal mesothelium. Using co-culture systems of primary human cells, we discovered that tumor-associated NK cells induce TRAIL-dependent apoptosis in mesothel...

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Bibliographic Details
Main Authors: Anna Mary Steitz, Clarissa Schröder, Isabel Knuth, Corinna U. Keber, Leah Sommerfeld, Florian Finkernagel, Julia M. Jansen, Uwe Wagner, Sabine Müller-Brüsselbach, Thomas Worzfeld, Magdalena Huber, Vanessa M. Beutgen, Johannes Graumann, Elke Pogge von Strandmann, Rolf Müller, Silke Reinartz
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:iScience
Subjects:
Microenvironment
Immunology
Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223024781

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http://www.sciencedirect.com/science/article/pii/S2589004223024781

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