Lactate-upregulated NADPH-dependent NOX4 expression via HCAR1/PI3K pathway contributes to ROS-induced osteoarthritis chondrocyte damage

Lactate-upregulated NADPH-dependent NOX4 expression via HCAR1/PI3K pathway contributes to ROS-induced osteoarthritis chondrocyte damage

Increasing evidence shows that metabolic factors are involved in the pathological process of osteoarthritis (OA). Lactate has been shown to contribute to the onset and progression of diseases. While whether lactate is involved in the pathogenesis of OA through impaired chondrocyte function and its m...

Full description

Bibliographic Details
Main Authors: Yi-Fan Huang, Guan Wang, Lu Ding, Zi-Ran Bai, Yi Leng, Jun-Wei Tian, Jian-Zeng Zhang, Yan-Qi Li, Ahmad, Yuan-Hua Qin, Xia Li, Xin Qi
Format: Article
Language:English
Published: Elsevier 2023-11-01
Series:Redox Biology
Subjects:
Lactate
Osteoarthritis
Chondrocytes
NADPH oxidase 4
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231723002689

Internet

http://www.sciencedirect.com/science/article/pii/S2213231723002689

Similar Items