Human liver microsomes study on the inhibitory effect of plantainoside D on the activity of cytochrome P450 activity

Human liver microsomes study on the inhibitory effect of plantainoside D on the activity of cytochrome P450 activity

Abstract Background Plantainoside D is widely existed in the herbs and possesses various pharmacological activities, making it possible to co-administrate with other herbs. Its effect on cytochrome P450 enzymes (P450) is a risk factor for inducing adverse drug-drug interactions. To assess the effect...

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Bibliographic Details
Main Authors: Jin Zhou, Xian Qian, Yanqing Zhou, Shili Xiong, Shuxia Ji, Ying Wang, Ping Zhao
Format: Article
Language:English
Published: BMC 2022-07-01
Series:BMC Complementary Medicine and Therapies
Subjects:
CYP450 activity
Microsomes
Cocktail method
IC50
Time-dependent inhibition
Online Access:https://doi.org/10.1186/s12906-022-03671-5

Internet

https://doi.org/10.1186/s12906-022-03671-5

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