Mutant BCL11B in a Patient With a Neurodevelopmental Disorder and T-Cell Abnormalities

Mutant BCL11B in a Patient With a Neurodevelopmental Disorder and T-Cell Abnormalities

Background:BCL11B encodes B-cell lymphoma/leukemia 11B, a transcription factor that participates in the differentiation and migration of neurons and lymphocyte cells. De novo mutations of BCL11B have been associated with neurodevelopmental disorder and immunodeficiency, such as immunodeficiency 49 (...

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Bibliographic Details
Main Authors: Sai Yang, Qingyun Kang, Yanqi Hou, Lili Wang, Liping Li, Shulei Liu, Hongmei Liao, Zhenhua Cao, Liming Yang, Zhenghui Xiao
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Pediatrics
Subjects:
BCL11B
neurodevelopmental disease
immunodeficiency
developmental disorder
immune system abnormalities
Online Access:https://www.frontiersin.org/article/10.3389/fped.2020.544894/full

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https://www.frontiersin.org/article/10.3389/fped.2020.544894/full

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