DESI-TQ-MS imaging for ex vivo brain biodistribution assessment: evaluation of LBT-999, a ligand of the dopamine transporter (DAT)

DESI-TQ-MS imaging for ex vivo brain biodistribution assessment: evaluation of LBT-999, a ligand of the dopamine transporter (DAT)

Abstract Background Selection of the most promising radiotracer candidates for radiolabeling is a difficult step in the development of radiotracer pharmaceuticals, especially for the brain. Mass spectrometry (MS) is an alternative to study ex vivo the characteristics of candidates, but most MS studi...

Full description

Bibliographic Details
Main Authors: Laurent Galineau, Emmanuelle Claude, Zuhal Gulhan, Sylvie Bodard, Sophie Sérrière, Camille Dupuy, Jérémy Monteiro, Adeline Oury, Priscila Bertevello, Gabrielle Chicheri, Johnny Vercouillie, Lydie Nadal-Desbarats, Sylvie Chalon, Antoine Lefèvre, Patrick Emond
Format: Article
Language:English
Published: SpringerOpen 2024-08-01
Series:EJNMMI Radiopharmacy and Chemistry
Subjects:
Radiotracer development
Mass spectrometry
Desorption electrospray ionization
Triple quadrupole type analyzer
LBT-999
Online Access:https://doi.org/10.1186/s41181-024-00289-5

Internet

https://doi.org/10.1186/s41181-024-00289-5

Similar Items