TREM2 risk variants and associated endophenotypes in alzheimer’s disease

TREM2 risk variants and associated endophenotypes in alzheimer’s disease

Abstract Background Rare variants of the triggering receptor expressed on myeloid cell 2 (TREM2) gene are strong risk factors for Alzheimer’s disease (AD), and drugs targeting the TREM2 protein are being developed. However, it is unknown what the effect of TREM2 variants is on the AD phenotype. Meth...

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Detalhes bibliográficos
Principais autores: Janna I. R. Dijkstra, Lisa Vermunt, Vikram Venkatraghavan, Georgii Ozhegov, Emma M. Coomans, Rik Ossenkoppele, Elsmarieke van de Giessen, Marc Hulsman, Christa M. de Geus, Wiesje M. van der Flier, Sietske A. M. Sikkes, Frederik Barkhof, Betty Tijms, Alida A. Gouw, Willem de Haan, Everard G. B. Vijverberg, Yolande A. L. Pijnenburg, Henne Holstege, Charlotte E. Teunissen, Sven J. van der Lee
Formato: Artigo
Idioma:English
Publicado em: BMC 2025-03-01
coleção:Alzheimer’s Research & Therapy
Assuntos:
TREM2
Alzheimer’s disease
Clinical measures
Acesso em linha:https://doi.org/10.1186/s13195-025-01700-2

Internet

https://doi.org/10.1186/s13195-025-01700-2

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