Mouse Ataxin-2 Expansion Downregulates CamKII and Other Calcium Signaling Factors, Impairing Granule—Purkinje Neuron Synaptic Strength

Mouse Ataxin-2 Expansion Downregulates CamKII and Other Calcium Signaling Factors, Impairing Granule—Purkinje Neuron Synaptic Strength

Spinocerebellar ataxia type 2 (SCA2) is caused by polyglutamine expansion in Ataxin-2 (ATXN2). This factor binds RNA/proteins to modify metabolism after stress, and to control calcium (Ca<sup>2+</sup>) homeostasis after stimuli. Cerebellar ataxias and corticospinal motor neuron degenerat...

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Bibliographic Details
Main Authors: Aleksandar Arsović, Melanie Vanessa Halbach, Júlia Canet-Pons, Dilhan Esen-Sehir, Claudia Döring, Florian Freudenberg, Nicoletta Czechowska, Kay Seidel, Stephan L. Baader, Suzana Gispert, Nesli-Ece Sen, Georg Auburger
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:International Journal of Molecular Sciences
Subjects:
amyotrophic lateral sclerosis (ALS)
fronto-temporal-lobar-dementia
tauopathies
synaptic plasticity
long-term potentiation
spatial learning
Online Access:https://www.mdpi.com/1422-0067/21/18/6673

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https://www.mdpi.com/1422-0067/21/18/6673

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