Bioisosterism of Fluorine and Cyano as Indole Substituents. Theoretical, in vitro and in vivo Examination

Bioisosterism of Fluorine and Cyano as Indole Substituents. Theoretical, in vitro and in vivo Examination

Fluorine substitution modifies structural attributes and often induces unexpected effects. When substituting fluorine with cyano in position 5 of the indole in indole-butyl-amines, the properties of the compounds proved to be very comparable. In vitro target-profile, metabolism, and in viv...

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Bibliographic Details
Main Authors: Timo Heinrich, Henning Böttcher, Gerd D. Bartoszyk, Harry Schwartz, Soheila Anzali, Joachim März, Hartmut E. Greiner, Christoph A. Seyfried
Format: Article
Language:deu
Published: Swiss Chemical Society 2004-03-01
Series:CHIMIA
Subjects:
Antidepressant
Bioisosterism
Metabolism
Pseudohalogen
Ultrasonic vocalisation
Online Access:https://chimia.ch/chimia/article/view/3820

Internet

https://chimia.ch/chimia/article/view/3820

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