Bioisosterism of Fluorine and Cyano as Indole Substituents. Theoretical, in vitro and in vivo Examination

Bioisosterism of Fluorine and Cyano as Indole Substituents. Theoretical, in vitro and in vivo Examination

Fluorine substitution modifies structural attributes and often induces unexpected effects. When substituting fluorine with cyano in position 5 of the indole in indole-butyl-amines, the properties of the compounds proved to be very comparable. In vitro target-profile, metabolism, and in viv...

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Detaylı Bibliyografya
Asıl Yazarlar: Timo Heinrich, Henning Böttcher, Gerd D. Bartoszyk, Harry Schwartz, Soheila Anzali, Joachim März, Hartmut E. Greiner, Christoph A. Seyfried
Materyal Türü: Makale
Dil:deu
Baskı/Yayın Bilgisi: Swiss Chemical Society 2004-03-01
Seri Bilgileri:CHIMIA
Konular:
Antidepressant
Bioisosterism
Metabolism
Pseudohalogen
Ultrasonic vocalisation
Online Erişim:https://chimia.ch/chimia/article/view/3820

Internet

https://chimia.ch/chimia/article/view/3820

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