Bioisosterism of Fluorine and Cyano as Indole Substituents. Theoretical, in vitro and in vivo Examination
Fluorine substitution modifies structural attributes and often induces unexpected effects. When substituting fluorine with cyano in position 5 of the indole in indole-butyl-amines, the properties of the compounds proved to be very comparable. In vitro target-profile, metabolism, and in viv...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | deu |
| Published: |
Swiss Chemical Society
2004-03-01
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| Series: | CHIMIA |
| Subjects: | |
| Online Access: | https://chimia.ch/chimia/article/view/3820 |
| _version_ | 1797987686186745856 |
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| author | Timo Heinrich Henning Böttcher Gerd D. Bartoszyk Harry Schwartz Soheila Anzali Joachim März Hartmut E. Greiner Christoph A. Seyfried |
| author_facet | Timo Heinrich Henning Böttcher Gerd D. Bartoszyk Harry Schwartz Soheila Anzali Joachim März Hartmut E. Greiner Christoph A. Seyfried |
| author_sort | Timo Heinrich |
| collection | DOAJ |
| description |
Fluorine substitution modifies structural attributes and often induces unexpected effects. When substituting fluorine with cyano in position 5 of the indole in indole-butyl-amines, the properties of the compounds proved to be very comparable. In vitro target-profile, metabolism,
and in vivo activity in the ultrasonic vocalisation test indicate bioisosterism between the two substituents.
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| first_indexed | 2024-04-11T07:52:07Z |
| format | Article |
| id | doaj.art-e9d983e6341f4dbdb38943d1e600ac0f |
| institution | Directory Open Access Journal |
| issn | 0009-4293 2673-2424 |
| language | deu |
| last_indexed | 2024-04-11T07:52:07Z |
| publishDate | 2004-03-01 |
| publisher | Swiss Chemical Society |
| record_format | Article |
| series | CHIMIA |
| spelling | doaj.art-e9d983e6341f4dbdb38943d1e600ac0f2022-12-22T04:36:03ZdeuSwiss Chemical SocietyCHIMIA0009-42932673-24242004-03-0158310.2533/000942904777678118Bioisosterism of Fluorine and Cyano as Indole Substituents. Theoretical, in vitro and in vivo ExaminationTimo HeinrichHenning BöttcherGerd D. BartoszykHarry SchwartzSoheila AnzaliJoachim MärzHartmut E. GreinerChristoph A. Seyfried Fluorine substitution modifies structural attributes and often induces unexpected effects. When substituting fluorine with cyano in position 5 of the indole in indole-butyl-amines, the properties of the compounds proved to be very comparable. In vitro target-profile, metabolism, and in vivo activity in the ultrasonic vocalisation test indicate bioisosterism between the two substituents. https://chimia.ch/chimia/article/view/3820AntidepressantBioisosterismMetabolismPseudohalogenUltrasonic vocalisation |
| spellingShingle | Timo Heinrich Henning Böttcher Gerd D. Bartoszyk Harry Schwartz Soheila Anzali Joachim März Hartmut E. Greiner Christoph A. Seyfried Bioisosterism of Fluorine and Cyano as Indole Substituents. Theoretical, in vitro and in vivo Examination CHIMIA Antidepressant Bioisosterism Metabolism Pseudohalogen Ultrasonic vocalisation |
| title | Bioisosterism of Fluorine and Cyano as Indole Substituents. Theoretical, in vitro and in vivo Examination |
| title_full | Bioisosterism of Fluorine and Cyano as Indole Substituents. Theoretical, in vitro and in vivo Examination |
| title_fullStr | Bioisosterism of Fluorine and Cyano as Indole Substituents. Theoretical, in vitro and in vivo Examination |
| title_full_unstemmed | Bioisosterism of Fluorine and Cyano as Indole Substituents. Theoretical, in vitro and in vivo Examination |
| title_short | Bioisosterism of Fluorine and Cyano as Indole Substituents. Theoretical, in vitro and in vivo Examination |
| title_sort | bioisosterism of fluorine and cyano as indole substituents theoretical in vitro and in vivo examination |
| topic | Antidepressant Bioisosterism Metabolism Pseudohalogen Ultrasonic vocalisation |
| url | https://chimia.ch/chimia/article/view/3820 |
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