A DNA phosphorothioation-based Dnd defense system provides resistance against various phages and is compatible with the Ssp defense system

A DNA phosphorothioation-based Dnd defense system provides resistance against various phages and is compatible with the Ssp defense system

ABSTRACT DndABCDE-catalyzed DNA phosphorothioation (PT), in which the nonbridging oxygen is swapped with a sulfur atom, was first identified in the bacterial genome. Usually, this modification gene cluster is paired with a restriction module consisting of DndF, DndG, and DndH. Although the mechanism...

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Bibliographic Details
Main Authors: Susu Jiang, Ke Chen, Yingying Wang, Yueying Zhang, Yaru Tang, Wanqiu Huang, Xiaolin Xiong, Shi Chen, Chao Chen, Lianrong Wang
Format: Article
Language:English
Published: American Society for Microbiology 2023-08-01
Series:mBio
Subjects:
DNA phosphorothioation
Dnd systems
Ssp systems
restriction-modification systems
DNA methylation
phage resistance
Online Access:https://journals.asm.org/doi/10.1128/mbio.00933-23

Internet

https://journals.asm.org/doi/10.1128/mbio.00933-23

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