Exploring <i>Cryptococcus neoformans</i> CYP51 and Its Cognate Reductase as a Drug Target

Exploring <i>Cryptococcus neoformans</i> CYP51 and Its Cognate Reductase as a Drug Target

<i>Cryptococcus</i> remains a leading cause of invasive fungal infections in immunocompromised people. Resistance to azole drugs has imposed a further challenge to the effective treatment of such infections. In this study, the functional expression of full-length hexahistidine-tagged <...

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Bibliographic Details
Main Authors: Yasmeen N. Ruma, Mikhail V. Keniya, Brian C. Monk
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Journal of Fungi
Subjects:
<i>Cryptococcus neoformans</i>
CYP51
cognate reductase
antifungal resistance
<i>Saccharomyces cerevisiae</i> expression system
screening tool
Online Access:https://www.mdpi.com/2309-608X/8/12/1256

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https://www.mdpi.com/2309-608X/8/12/1256

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