Mutations in α-synuclein, TDP-43 and tau prolong protein half-life through diminished degradation by lysosomal proteases

Mutations in α-synuclein, TDP-43 and tau prolong protein half-life through diminished degradation by lysosomal proteases

Abstract Background Autosomal dominant mutations in α-synuclein, TDP-43 and tau are thought to predispose to neurodegeneration by enhancing protein aggregation. While a subset of α-synuclein, TDP-43 and tau mutations has been shown to increase the structural propensity of these proteins toward self-...

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Detalhes bibliográficos
Main Authors: Paul J. Sampognaro, Shruti Arya, Giselle M. Knudsen, Emma L. Gunderson, Angelica Sandoval-Perez, Molly Hodul, Kathryn Bowles, Charles S. Craik, Matthew P. Jacobson, Aimee W. Kao
Formato: Artigo
Idioma:English
Publicado em: BMC 2023-05-01
Colecção:Molecular Neurodegeneration
Assuntos:
Cathepsin
Protease
α-synuclein
TDP-43
Tau
Lysosome
Acesso em linha:https://doi.org/10.1186/s13024-023-00621-8

Internet

https://doi.org/10.1186/s13024-023-00621-8

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