Timing of Interleukin-4 Stimulation of Macrophages Determines Their Anti-Microbial Activity during Infection with <i>Salmonella enterica</i> Serovar Typhimurium

Timing of Interleukin-4 Stimulation of Macrophages Determines Their Anti-Microbial Activity during Infection with <i>Salmonella enterica</i> Serovar Typhimurium

Priming of macrophages with interferon-gamma (IFNγ) or interleukin-4 (IL-4) leads to polarisation into pro-inflammatory or anti-inflammatory subtypes, which produce key enzymes such as inducible nitric oxide synthase (iNOS) and arginase 1 (ARG1), respectively, and in this way determine host response...

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Bibliographic Details
Main Authors: Natascha Brigo, Emely Neumaier, Christa Pfeifhofer-Obermair, Philipp Grubwieser, Sabine Engl, Sylvia Berger, Markus Seifert, Vera Reinstadler, Herbert Oberacher, Günter Weiss
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Cells
Subjects:
interleukin-4
arginase 1
interferon-gamma
inducible nitric oxide synthase
<i>Salmonella enterica</i> serovar Typhimurium
macrophages
Online Access:https://www.mdpi.com/2073-4409/12/8/1164

Internet

https://www.mdpi.com/2073-4409/12/8/1164

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