One Billion hiPSC-Cardiomyocytes: Upscaling Engineered Cardiac Tissues to Create High Cell Density Therapies for Clinical Translation in Heart Regeneration

One Billion hiPSC-Cardiomyocytes: Upscaling Engineered Cardiac Tissues to Create High Cell Density Therapies for Clinical Translation in Heart Regeneration

Despite the overwhelming use of cellularized therapeutics in cardiac regenerative engineering, approaches to biomanufacture engineered cardiac tissues (ECTs) at clinical scale remain limited. This study aims to evaluate the impact of critical biomanufacturing decisions—namely cell dose, hydrogel com...

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Bibliographic Details
Main Authors: Kiera D. Dwyer, Rajeev J. Kant, Arvin H. Soepriatna, Stephanie M. Roser, Mark C. Daley, Sharif A. Sabe, Cynthia M. Xu, Bum-Rak Choi, Frank W. Sellke, Kareen L. K. Coulombe
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Bioengineering
Subjects:
hiPSC-cardiomyocytes
engineered cardiac tissue
tissue engineering
scale up
biomanufacturing
cell-dense tissue
Online Access:https://www.mdpi.com/2306-5354/10/5/587

Internet

https://www.mdpi.com/2306-5354/10/5/587

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